![]() However, data on neurological symptoms that persist (or develop) three months or more after acute COVID-19 have not yet been systematically consolidated. Previous studies have documented residual symptoms that continue (or develop) 4–12 weeks after the onset of acute COVID-19, known as “post-acute or long COVID-19”. These features have been identified in patients regardless of acute COVID-19 severity. Of equal and urgent concern is the burden associated with COVID-19 symptoms that persist beyond the onset of infection, called COVID-19 long haul (LH) symptoms or post-COVID-19 syndrome. Cohorts with >20% of patients admitted to the ICU during acute COVID-19 experienced higher prevalence of fatigue, anxiety, depression, and sleep disturbances than cohorts with <20% of ICU admission.Īcute coronavirus disease-2019 (COVID-19) continues to overwhelm healthcare systems and is responsible for significant morbidity and mortality. Compared to non-hospitalised patients, patients hospitalised for acute COVID-19 had reduced frequency of anosmia, anxiety, depression, dysgeusia, fatigue, headache, myalgia, and sleep disturbance at three (or more) months post-infection. Neuropsychiatric symptoms substantially increased in prevalence between mid- and long-term follow-up. ![]() ![]() Of 1458 articles, 18 studies, encompassing a total of 10,530 patients, were analysed. ![]()
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